Humanity is winning the fight against Malaria, but we still have a long way to go. Since the advent of the Global Fund, the Millennium Development Goals and the President's Malaria Initiative, death and illness rates have dropped precipitously around the globe. Now, talk of total worldwide eradication is not as preposterous as it may seem. This is the message that Martin Edlund of Malaria No More has for the policy community ahead of World Malaria Day on April 25. Despite the progress, though, he argues that there are still big challenges ahead -- particularly the spread of drug resistant Malaria in the Mekong Delta. This is a great episode for anyone who wants to learn why a disease that haunted humanity for millennia is now on the ropes.