Matt Maiocco and Laura Britt discuss the latest from 49ers OTAs, including the progress of Trey Lance and the impact injuries have had on the second week. Then, the duo turn their attention to new defensive coordinator DeMeco Ryans and break down how he will change the 49ers' defense this season.(1:48) Updating 49ers’ injury situation during OTAs  (7:12) How is Lance progressing? (15:04) Discussing Ryan’s comments on the 49ers' new defensive mentality(23:20) How versatile is the 49ers' defense? (27:10) Which players on defense are primed for breakout season?  (31:30) 49ers sign TE Michael Pruit, WR Andy Jones (34:30) Latest update in the Julio Jones sweepstakes  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.