"Tell me about the problems you have with your medications." A simple open-ended question that is probably rarely asked, but goes beyond the traditional problems that clinicians worry about, like non-adherence, inappropriate prescribing, and adverse reactions. What do you find when you go deeper? Well we talk with Francesca Nicosia and Mike Steinman about the work they have done around deprescribing and medication related problems, including a recent JGIM study that attempts to better understand patient perspectives on medication-related problems. This study also gives a pretty fascinating picture of where the overlap and divergence is between what patients and physician see as medication related problems as shown in this figure from the article: In addition to medication related problems, we talk about some other important updates in deprescribing, including their work in the newly formed US Deprescribing Research Network and new pilot awards of up to $60,000 in funds to catalyze investigator initiated research projects around deprescribing. by: Eric Widera (@ewidera)