The Dow, S&P and Nasdaq all closed down more than 1% and Jim Cramer is explaining why he's telling investors to keep calm and carry on. Then, the omicron variant is already breaking daily case records in some areas and Dr. Eric Topol makes sense of the surge. Next, you’re probably used to watching Hallmark holiday love stories this time of year, but Cramer has 3 break up stories from three of the biggest pharmaceutical names that you should have your eye on too. Finally, cryptocurrency made its mark in 2021, but what’s in store for 2022? Founder and CEO of cryptocurrency and asset exchange FTX Sam Bankman-Fried shares what he's seeing.