This two-part video and podcast series provides an overview of prematurity, considerations surrounding stabilization of preterm infants, and a systems-based approach to common conditions associated with prematurity. In this first part, the definition of prematurity and its epidemiology in Canada, as well as risk factors and characteristics of extremely preterm, very preterm, and term infants are covered. This video and podcast were developed by Jhanahan Sriranjan, a medical student at McMaster University, with the support of Dr. Kristin Inch, a pediatrician at the Special Care Nursery at St. Joseph’s Hospital in Hamilton Ontario.