This podcast is the second in a two-part series on cystic fibrosis. In this podcast, the listener will learn about the clinical features and complications of CF, the prognosis of CF, and an approach to prevent, investigate, and manage acute respiratory exacerbations. The podcast was created by Dr. Rose Sun, a second-year pediatrics resident at the Hospital for Sick Children in Toronto, with support from Drs. Tamizan Kherani and Melinda Solomon, pediatric respirologists at the Stollery Children's Hospital in Edmonton and the Hospital for Sick Children respectively.