In this VETgirl online veterinary continuing education podcast, we discuss the prevalence of immune-complex glomerulonephritis (ICGN) in dogs. Is it always due to glomerulonephritis? Or is it due to amyloidosis? Why should we care? First, we should care as glomerular injury is common to many renal diseases. Both primary and secondary glomerular disease is commonly seen in dogs. Primary glomerular disease refers to diseases where the glomerulus suffers the initial injury, while secondary glomerular disease refers to those diseases in which the glomerulus is secondarily injured. Based on the ongoing WSAVA Renal Standardization Project, primary glomerular disease in dogs is divided into 3 main groups: immune-complex glomerulonephritis, amyloidosis, and non-immune-complex glomerulonephritis. You can download the guidelines here, btw. Non-immune-complex glomerulonephritis is a diagnosis of exclusion, if neither immune complexes nor amyloid is demonstrated, but primary pathology is noted in the glomerulus.