In today's VETgirl online veterinary continuing education podcast, we discuss aortic thrombotic disease (what we'll call ATD from now on). We know that patients with ATD develop this due to Virchow's Triad - the combination of vascular endothelial injury, altered blood coagulability and changes in blood flow. Common underlying causes resulting in vascular endothelial injury include trauma, dirofilarial infection, hypotension, vasculitis, inflammation, acidosis, hypoxemia, dextrose fluid administration, arteriosclerosis (more in humans), and immune mechanisms. Altered blood coagulability may be due to platelet dysfunction (or hyperfunction), or any factor along the coagulation cascade or fibrinolytic system that has gone awry. Lastly, changes in blood flow may be due to blood stasis (e.g., an enlarged atrium), compressive lesions, trauma, or turbulence.