Master this practical approach to reading the medical literature (*No statistics needed!) with expert tips from Dr. Christine Laine, Editor in Chief, Annals of Internal Medicine, and Dr. Darren Taichman, Executive Deputy Editor, Annals of Internal Medicine. They teach us what we should be reading, and detail their thought processes as they appraise an article. Topics covered include: Is 3 minute critical appraisal possible? What’s the deal with P-values? What are common sources of bias? How does the approach differ with clinical trials versus observational studies versus meta-analyses? *Minimal statistics needed ; ) Full show notes available at http://thecurbsiders.com/podcast Join our newsletter mailing list. Rate us on iTunes, recommend a guest or topic and give feedback at thecurbsiders@gmail.com. Time Stamps 00:00 Intro 01:13 Listener comment on Entresto 02:50 Picks of the week 09:36 Getting to know our guests 14:00 How to stay up on the medical literature 17:15 Three minute critical appraisal 19:15 Step 1: Assess the outcome being studied 20:50 Statistical versus clinical significance 22:33 Evaluating composite endpoints 24:47 Statistical power 28:58 Evaluating for bias 34:40 Recap of what we’ve learned so far 36:33 Is PICO useful? 39:01 Observational studies and bias 41:09 Evaluating a meta-analysis 46:05 Take home points 50:35 The Curbsiders recap the episode 53:02 Outro Tags: literature, appraisal, meta, analysis, analyze, critical, read, medical, journal, study, randomized, observational, systematic, review, clinical, trial, assistant, care, education, doctor, family, foam, foamed, health, hospitalist, hospital, internal, internist, nurse, medicine, medical, primary, physician, resident, student