We review myths and reality in the management of patients with Sickle Cell Disease (SCD)  Are these patients typically opioid seeking? (No) If the patient appears comfortable I should withhold proper analgesia. (No). Should IV fluids be a routine part of the cocktail for vaso-occlusive pain episodes? (No) We also review common emergencies in sickle cell disease that include Infections Acute chest syndrome Anemia (Aplastic crisis, splenic sequestration) Ischemia Strokes Avascular necrosis Renal, pulmonary, splenic infarctions Vaso-occlusive pain episodes Thanks for listening! Lauren Westafer and Jeremy Faust