EARLY use of Tranexamic Acid may improve survival from bleeding in trauma

FromICU Rounds

Start listening View podcast show

EARLY use of Tranexamic Acid may improve survival from bleeding in trauma

FromICU Rounds

ratings:

Length:

20 minutes

Released:

Feb 20, 2012

Format:

Podcast episode

Description

In this episode we talk about the results of the CRASH-2 trial published in Lancet. This trial showed that the EARLY use of Tranexamic acid may improve survivial, but delayed use may be associated with an increased mortality.

Released:

Feb 20, 2012

Format:

Podcast episode

Titles in the series (97)

also available for free download on iTunes. (http://itunes.apple.com/us/podcast/icu-rounds/id254707344)

Skip carousel

Antibiotic Considerations in the ICU: Why do we choose the antibiotics that we do? How long do we continue the course of therapy? Should we use some antibiotics together? These topics are covered in the episode. by ICU Rounds
54 min listen
Intraosseous Vascular Access: not just for the kids anymore: Intraosseous vascular access was was developed for use in adult trauma patients over 80 years ago. Only recently has this technique regained popularity for rapid and safe access to the vascular space in patients in extremis. by ICU Rounds
18 min listen
Complications of PEEP and Auto-PEEP: Virtually all patients on ventilators are on PEEP. PEEP has several interactions with various organ systems and some can result in profound complications. An understanding of PEEP and auto-PEEP are required before we can understand modes of... by ICU Rounds
19 min listen
What is the role of decadron in preventing post extubation stridor?: What is the role of giving an adult steroids to prevent stridor or reintubation following extubation. This epidose looks at the data. by ICU Rounds
9 min listen
Acute RenalFailure: Acute renal failure is a dreaded complication in the ICU. This podcast will review the various types of acute renal failure, the etiology, as well as acute management. by ICU Rounds
42 min listen
Weaning (Liberating) from the mechanical ventilator: Don't wean people from their ventilators-- liberate them!! When are people ready to come off the ventilator? What are weaning parameters? How does one do a spontaneous weaning trial? What is the role of noninvasive... by ICU Rounds
26 min listen
HIT: Heparin Induced Thrombocytopenia: Large numbers of patients in ICUs are on heparin and what is this complication of heparin induced thrombocytopenia? by ICU Rounds
20 min listen
Blood Products: Blood products: pRBCs, fresh frozen plasma, platelets, cryoprecipitate when and how should we use it? What are the risks? You may order them like IV fluids but do you really know how these potentially deadly products are to be... by ICU Rounds
38 min listen
Glutamine In Critical Illness: what's all the fuss about?: All surgical residents know that glutamine is the amino acid known as the fuel for the gut. But what is all the fuss about? The episode will look at the data on glutamine. Does glutamine improve outcomes, and if so and in... by ICU Rounds
11 min listen
Renal Replacement Therapy: SCUF, SLED, CVVH, CVVHD, IHD--what does it all mean: Renal replacement therapy (RRT) is rather a confusing topic. What do all those initials mean and why use one therapy over another? This podcast will explain the difference between intermittent and continous. What are the... by ICU Rounds
32 min listen
Bomb and Blast Injuries: Bomb and blast injuries: In the past blast injuries were limited to the battlefield of a rare industrial accident. The events of the past week are a reminder that civilian population centers are targets for bombing attacks. ... by ICU Rounds
32 min listen
Airway Pressure Release Ventilation (APRV) or BiVent: What the heck is this?: Airway pressure release ventilation (APRV) is not a new mode of mechanical ventilation, but it seems to be gaining a great deal of popularity lately. Many people find this mode very complicated and thick that it is reserved only for the very... by ICU Rounds
23 min listen
Thermal Injuries: An introduction of the biology of thermal injuries and the initial care of the patient with thermal injuries in critical condition. by ICU Rounds
40 min listen
Modes of Mechanical Ventilation: A discussion of the various types of ventilators with a focus on the various ventilator modes and types of ventilator cycles. Also presented is the topic of pressure support ventilation (PSV) by ICU Rounds
24 min listen
Lightning Injuries: Lightning injuries are rare, but when you do treat a patient they can have facinating presentations. This lecture follows a patient we treated at Vanderbilt. The patient present to a local ED with stroke like symptoms... by ICU Rounds
11 min listen
Control of hyperglycemia improves outcomes: A great deal is being presented and published on control of blood sugar in the ICU as well as the postoperative period. How much control is enough and what is the data? by ICU Rounds
34 min listen
PAIN: a four letter word: The management of pain is a key element of the care of all patients-- ICU or not. Often providers have little understanding of the concepts and medications of pain management. This episode serves as an introduction. by ICU Rounds
40 min listen
Metabolism: Starvation versus Stress: Not feeding an injured or ill patient is not that same as a normal individual who is fasting. A pound of weight loss in the stress patient is significantly different than a pound of weight loss in someone on a diet. A basic... by ICU Rounds
29 min listen
Early Surgery Improves Outcomes Following Critical Burns: Early surgical excision is likely to be the most significant individual variable to imporve the outcome of a patient (adult or child) with a critical burn. Nevertheless, many nonburn physicians still want to apply to 1970 treatment paradigms to... by ICU Rounds
24 min listen
Crush Syndrome: Earthquakes are horrible natural events causing loss of lives in the thousands. Following earthquakes, building collapses, and cave-ins, large number of victims will suffer from renal failure and death following crush syndrome. by ICU Rounds
19 min listen
Burns: Fluid Creep: Excessive fluid resuscitations lead to horrible complications such as abdominal compartment syndrome. This article takes a critical look and challanges many of our practices in fluid resuscitation of burn patients. by ICU Rounds
22 min listen
Traumatic Shock and Fluid Resuscitation: Fluid resuscitation done poorly can result in significant complications to the patient. This episode will present some of the newer considerations in fluid resuscitation in traumatic shock. by ICU Rounds
42 min listen
Blood Conservation in the ICU: When should a patient receive a transfuse of blood? What is an acceptable hemoglobin concentration in an ICU patient and should we use EPO? Summer is a time when the blood banks often have a single day's worth of blood. Perhaps with... by ICU Rounds
28 min listen
Atrial Fibrillation: Atrial fibrillation is a common problem in ICU patients, but it is a problem with many potential causes, and not always a well defined treatment. by ICU Rounds
39 min listen
Traumatic Rhabdomyolyisis / Crush Syndrome: Crush syndrome is a common cause of death following earth quakes, mine and building collapses. Traumatic rhabdomyolysis may also be seen following electrical injury or severe trauma. (This is a reposting due to some previous technical problems with... by ICU Rounds
27 min listen
Do Steroid Improve Survivial in Sepsis? CORTICUS Trial: The results of the CORTICUS trial are discussed. by ICU Rounds
23 min listen
Oxygenation & PEEP: A discussion of ventilation, oxygenation, and the role of PEEP. by ICU Rounds
26 min listen
Smoke Inhalation Injury: CO and Cyanide Toxicity: The onset of cold weather will bring with it an increase in structure fires. The leading cause of deaths in fires is complications from the inhalation of smoke-- not burns. Learn why smoke is so deadly as well as what are the appropriate... by ICU Rounds
39 min listen
Metabolic Acidosis in the ICU: A common problem in the ill or injured patient is a metabolic acidosis. In this episode we will review the common etiology of a metabolic acidosis as well as some lesser known causes. by ICU Rounds
37 min listen
Pharmacology of Shock: This is a basic introduction of some of the drugs used in various forms of shock. by ICU Rounds
38 min listen

More Episodes from ICU Rounds

Skip carousel

Splitting a Ventilator: Multipatient Ventilation for COVID?: Throughout the pandemic, there has been considerable discussion about the possibility of running our of ventilators. One potential solution that was brought forward was putting multiple patients on a single ventilator. This is a lot harder than merely... by ICU Rounds
16 min listen
Prone Ventilation for ARDS (COVID-19): This week we have a brief conversation about prone mechanical ventilation for ARDS. Does it provide a benefit? When should we use it, and why does it work? I hope this is helpful as prone ventilation has been reported to provide benefit to patients... by ICU Rounds
20 min listen
ARDS and Mechanical Ventilation / COVID-19 Care: Today we discuss the approach to oxygenating and mechanically ventilating a patient suffering from ARDS. We will cover elements relevant and essential in the management of COVID patients and all others with ARDS. by ICU Rounds
33 min listen
ICU Care of Coronavirus (COVID-19): I'm back. I plan on providing you with some useful information when caring for patients infected with COVID-19 (Coronavirus). In this episode, I will provide you an overview of the current evidence and best practices with some explanation and... by ICU Rounds
49 min listen
Colloids: Details and Myths: This episode provide some basic description of colloids as will as some myths. by ICU Rounds
18 min listen
Random Serum Cortisol Levels are misleading: A physiological explanation why random cortisol levels are NOT helpful in evaluating adrenal function by ICU Rounds
17 min listen
Pediatric IVC diameter determination with ultrasound: If you are using ultrasound to evaluate IVC diamter in children, what is considered a normal IVC diameter? You can determine the IVC/Ao ratio or correct the IVC diamter based on the child's body surface area. by ICU Rounds
16 min listen
Takotsubo Cardiomyopathy: This is a condition that mimics acute coronary syndrome (ACS) that may be caused by acute emotional or physical stress. Patient's may appear to have profound cardiogenic shock, but these patients have a very high survivial rate with little more... by ICU Rounds
13 min listen
Necrotizing Soft Tissue Infection (NTSI): This episode discusses the pathophysiology, presentation, and treatment of NTSI. by ICU Rounds
26 min listen
Different Cardiac Output Monitors & Physiology: This episode will discuss the physiology behind various CO output monitors such as pulmonary artery catheters, PICCO, pulse wave form analysis, and LiDCO. by ICU Rounds
31 min listen
Lactic Acidosis - Type B: Now these are the types of lactic acidosis that most people are not familiar. They can be caused by medications, underlying disease, or inborn errors of metabolism. by ICU Rounds
17 min listen
Lactate Acidosis - Type A: This podcast is a description of how lactate is produced and metabolized. I will discuss the role of lactate in the diagnosis and management of shock. This podcast will focus on Type A lactic acidosis. by ICU Rounds
22 min listen
Endotracheal tube cuff leaks and self-extubations: A brief description on what to consider when confronted with a patient with an air leak from the ET tube or a patient that self-extubates. by ICU Rounds
24 min listen
Pulmonary Embolus: A description of the risk factors, diagnosis, and treatment of PE. by ICU Rounds
33 min listen
Smoke Inhalation Injury: Smoke Inhalation injuries can be deadly. This episode explains why smoke can be so deadly, and how to care for those patients with suspected smoke inhalation injuries. by ICU Rounds
31 min listen
Propofol Related Infusion Syndrome: Propofol Related Infusion Syndrome is a potentially fatal complication of propofol. If you use this common ICU drug you need this information. by ICU Rounds
24 min listen
Wedge: Everyone elses favorite Swan number: Wedge or PAOP is perhaps the most quoted and poorly understood variable generated by a Swan-Ganz. by ICU Rounds
26 min listen
SVO2 My favorite Swan Number: The most helpful number for me on a Swan is the SvO2. This is a brief description of how I use this variable in evaluating critically ill and injured patients. by ICU Rounds
19 min listen
Therapeutic Hypothermia After Cardiac Arrest: Therapeutic hypothermia after cardiac arrest is part of ACLS and is used by several EMS agencies around the US. Despite good data and improved patient outcomes, many providers fail to used this modality. This podcast will focus on a... by ICU Rounds
34 min listen
Pancreatitis - Surgical Indications and Procedures: This is the third in the series on severe pancreatitis and necrotizing pancreatitis. This episode reviews the indications for surgery, morbidity and mortality of surgery, and what are the surgical options. by ICU Rounds
26 min listen
Severe Acute Pancreatitis: Part 2 ICU Considerations: A brief discussion of the considerations of ICU care of the patient with severe pancreatitis, fluid resuscitation, respiratory, renal, and nutrition. by ICU Rounds
18 min listen
Pancreatitis - Part 1: This is an initial presentation of the causes and diagnosis of acute pancreatitis. by ICU Rounds
26 min listen
That peripheral IV can kill you: Suppurative Thrombophlebitis: All the recent emphasis on venous catheter infections has been on central lines. Those peripheral IVs are also dangerous. by ICU Rounds
14 min listen
Acute Colonic Pseudoobstruction (Ogilvie's Syndrome): Acute Colonic Pseudoobstruction (ACPO) is commonly called Ogilvies Syndrome. ACPO presents massive dilation in critically ill patients, and might result in invasive procedures to avoid ischemia or perforation of the colon. by ICU Rounds
32 min listen
Hemoglobin Based Oxygen Carriers (a.k.a. Artificial Blood): A brief summary of what are hemoglobin based oxygen carriers (HBOC) and where are they in development. by ICU Rounds
24 min listen
Catheter-Related Bloodstream Infection: Diagnosis: Discussion of what is the difference between a CVC infection and a catheter-related blood stream infection. They are treated differently so it is important to know the difference. by ICU Rounds
19 min listen
Ventilator Associated Pneumonia: A discussion on nosocomial infections and VAP. by ICU Rounds
34 min listen
Complications of Dwelling Central Lines: What horrible things can happen with central lines once they have been inserted. by ICU Rounds
34 min listen
Central Line Insertion Complications: A discussion of the potential problems encountered while inserting central venous catheters. by ICU Rounds
32 min listen
Pulmonary Physiology and General Anesthesia: This episode discusses the effects and risks of anesthesia on patients with pulmonary disease as well as the effects of anesthesia on pulmonary physiology. by ICU Rounds
30 min listen

Related podcast episodes

Skip carousel

Can TXA save lives in head injuries, CRASH-3; Roadside to Resus: So an incredibly important paper, CRASH-3 has just been published in the Lancet, which looks at the treatment of head injuries with Tranexamic Acid (TXA). TXA has been shown to save lives in trauma patients at the risk of major haemorrhage, with the... by The Resus Room
40 min listen
Esomeprazole (Nexium) Pharmacology: On this episode, I discuss esomeprazole (Nexium) pharmacology, adverse effects, tapering, kinetics, and drug interactions. I spend a good amount of time discussing the esomeprazole and clopidogrel interaction in this podcast episode. by Real Life Pharmacology - Pharmacology Education for Health Care Professionals
16 min listen
#GU22: Advancing Care for Patients With mHSPC: Dr. Neeraj Agarwal, ASCO Daily News editor-in-chief, and director of the Genitourinary Cancers Program at the University of Utah’s Huntsman Cancer Institute, shares key takeaways from the practice-changing ARASENS trial in mHSPC, featured at the... by ASCO Daily News
6 min listen
26 CSC StrokeFM Time to AcT by Stroke FM
50 min listen
Asthma; Roadside to Resus Part 2: This is the second part of the Roadside to Resus discussion on asthma. Make sure you’ve listened to part 1 before delving into this one! Part 2 covers Ketamine Ultrasound in asthma NIV in asthma Asthma related cardiac arrest Imaging... by The Resus Room
24 min listen
Tranexamic Acid; time to treatment: In this episode we cover a paper that you have to know about! The use of tranexamic acid(or TXA) has become widespread in the case of major trauma and post partum haemorrhage. This time we discuss a recent paper that asks us if giving it within 3... by The Resus Room
12 min listen
Brexpiprazole (Rexulti) Pharmacology Podcast: Brexpiprazole (Rexulti) is a second generation antipsychotic. I discuss its pharmacology, adverse effects, drug interactions, and more in this podcast episode. I like to associate brexpiprazole with aripiprazole. by Real Life Pharmacology - Pharmacology Education for Health Care Professionals
15 min listen
Darifenacin Pharmacology Podcast – Episode 308: On this podcast episode, I discuss darifenacin pharmacology, adverse effects, drug interactions and much more. CYP3A4 and CYP2D6 are important enzymes in relation to darifenacin. I breakdown the importance of these enzymes and how they can impact d... by Real Life Pharmacology - Pharmacology Education for Health Care Professionals
13 min listen
Rucaparib Maintenance in Recurrent Ovarian Cancer (ARIEL3) with Andrew Clamp: Andrew Clamp (@TheChristieNHS and @OfficialUoM) … by IJGC Podcast
31 min listen
Advances in Genitourinary Cancers at ASCO22: Guest host Dr. Neeraj Agarwal, of the University of Utah Huntsman Cancer Institute and the ASCO Daily News editor-in-chief, discusses updated results from the ENZAMET trial and other advances in prostate cancer and highlights key studies in kidney and... by ASCO Daily News
23 min listen
Fundamentals of JAK inhibitors and what makes them TYK by Derms and Conditions
26 min listen
97: Status Asthmaticus Part 2: Strategies to Manage the Crashing Asthmatic by Rapid Response RN
28 min listen
Systemic Therapies for Advanced Prostate Cancer – Short and Long-Term Side Effects: Systemic Therapies for Advanced Prostate Cancer –… by AUAUniversity
37 min listen
Atorvastatin to Reduce Risk of Anthracycline-Associated Cardiac Dysfunction: Anthracyclines are used to treat a variety of cancers, but treatment may be limited by cardiac toxicity. JAMA Executive Editor Gregory Curfman, MD, discusses a new clinical trial on the use of atorvastatin to prevent anthracycline-induced cardiac... by JAMA Author Interviews
19 min listen
GOG 281: Use of Trametinib in Low-Grade Serous Cancer: In this episode of the IJGC podcast, Editor-in-Ch… by IJGC Podcast
42 min listen
Circulation September 15, 2020 Issue: Circulation Weekly: Your Weekly Summary & Backstage Pass To The Journal by Circulation on the Run
28 min listen
Podcast # 454: Tylenol Overdose: Educational Pearls: Acetaminophen overdose can also present in patients taking too much over the course of days to weeks - not just intentional ingestions If acute overdose is suspected, refer to the Rumak-Matthew nomogram to guide treatment... by Emergency Medical Minute
5 min listen
Latest Updates on Diabetes Management in Pregnancy by Diabetes Dialogue: Technology, Therapeutics, & Real-World Perspectives
20 min listen
1198. DHA: Your Body's Ultimate Oil Change: Dr. Martin looks at new studies on the benefits of omega-3 DHA in today’s episode. You get two sources of omega-3 from the animal kingdom. EPA is good, but Dr. Martin says DHA is best. It’s the best oil in the world and new studies are showing how... by The Doctor Is In Podcast
13 min listen
Differential translation of mRNA isoforms underlies oncogenic activation of cell cycle kinase Aurora A by PaperPlayer biorxiv cell biology
20 min listen
S2302 Pragmatica-Lung and the Promise of Streamlined Clinical Trials: Host Dr. John Sweetenham and guests Dr. Karen Reckamp and Dr. Harpreet Singh discuss the S2302 Pragmatica-Lung trial, a streamlined, real-world clinical trial that is poised to simplify and transform the entire clinical trials model as we know it.... by ASCO Daily News
27 min listen
Dr. Matt Kaeberlein—Novel Research on Longevity Agents in Domestic Dogs by Longevity by Design
59 min listen
The AMPK-TORC1 signalling axis regulates caffeine-mediated DNA damage checkpoint override and cell cycle effects in fission yeast by PaperPlayer biorxiv cell biology
20 min listen
Assessing Adherence to Clozapine: Practical Considerations: Clozapine is an important drug in the treatment of schizophrenia, and adherence is generally thought to be as good as, if not better than, other antipsychotics. Nonadherence, however, is difficult to detect and potentially dangerous. Tolerance to the... by The Journal of Clinical Psychopharmacology Podcast
7 min listen

Discover this podcast and so much more

EARLY use of Tranexamic Acid may improve survival from bleeding in trauma

EARLY use of Tranexamic Acid may improve survival from bleeding in trauma

Description

Titles in the series (97)

More Episodes from ICU Rounds

Related podcast episodes