This month, Deputy Editor Susan K. Schultz, M.D., discusses patient preference and functional connectivity of the subcallosal cingulate cortex as possible predictors of treatment response in major depression, a behavioral phenotype of autism spectrum disorder characteristic of patients with known genetic abnormalities, functioning of the brain’s reward system in anorexia nervosa, collaboration between psychiatry and law enforcement, and a model of irritability in children and teens. Articles may be viewed online at ajp.psychiatryonline.org. Also, visit the online edition of this month’s Journal to view a video of Deputy Editor Daniel S. Pine, M.D., presenting highlights from the issue (ajp.psychiatryonline.org/toc/ajp/174/6).