In this VetGirl podcast, we review the transmission and clinical signs seen from canine leptospirosis. When it comes to leptospirosis, there are both saprophytic and pathogenic leptospires. Pathogenic leptospires are shed from renal tubules of both domestic and wild animals, and can remain viable in the soil and environment for weeks to months. That said, leptospires are inactivated by UV radiation and freezing. Infection can also occur through intact mucous membranes or abraded skin with direct or indirect exposure to urine. Rarely, leptospirosis can be transmitted via bite wound, ingestions of infected tissue (e.g., eating raw meat), or by venereal or placental transfer).