It's hard to decide what chances are worth taking and even hard to figure out which ones aren't. One thing is for sure, you're probably not grabbing as much possibility that's within reach. Because it's much easier to not do something than it is to look hard enough to see a unique opportunity. It's also possible to become obsessed with the next great thing that never happens. That's what I talk to Ann Handley, of MarketingProfs, about how she stopped saying no.