Discover millions of ebooks, audiobooks, and so much more with a free trial

Only $11.99/month after trial. Cancel anytime.

Cisplatin: Current Status and New Developments
Cisplatin: Current Status and New Developments
Cisplatin: Current Status and New Developments
Ebook970 pages

Cisplatin: Current Status and New Developments

Rating: 0 out of 5 stars

()

Read preview

About this ebook

Cisplatin: Current Status and New Developments is a collection of papers presented at a symposium sponsored by the University of Alabama in Birmingham Comprehensive Cancer Center and the Bristol Laboratories in Syracuse, ?ew York, and held on September 27-28, 1979, in Atlanta, Georgia. The symposium provided a forum for assessing developments with regards to cisplatin as an anticancer drug, with emphasis on its clinical application in a wide variety of adult and pediatric malignancies as well as the mechanism by which the drug appears to cause tumor cell death. Comprised of 39 chapters, this book begins with a preclinical overview of cisplatin, focusing on its mechanism of action, pharmacology, antitumor activity, analogs, and toxicity. The discussion then turns to the effects of cisplatin on DNA and the possible relationships to cytotoxicity and mutagenicity in mammalian cells; lethal activity of platinum compounds in combination with pyrimidine derivatives; and ultrastructural effects of cisplatin. Subsequent chapters focus on the rationale of combination chemotherapy; toxic side effects of platinum analogs; radiopharmacokinetics of cisplatin; and the use of cisplatin for the treatment of malignancies such as ovarian cancer and advanced adenocarcinoma of the prostate. This monograph will be useful to oncologists and pharmacologists.
LanguageEnglish
Release dateOct 22, 2013
ISBN9781483289007
Cisplatin: Current Status and New Developments

Related to Cisplatin

Medical For You

View More

Reviews for Cisplatin

Rating: 0 out of 5 stars
0 ratings

0 ratings0 reviews

What did you think?

Tap to rate

Review must be at least 10 words

    Book preview

    Cisplatin - Archie W. Prestayko

    _book_preview_excerpt.html|KsH_YIR4(fU(#S} }˚͜6?a}~D=" AULlYW+I~{[ii{fݢ]^di2?7q 7|ǞѼ8,8JX}WʼﺓÕ܅σ,0}P^^L`<~7p<\~0ߏۛ ;V<>{~.ᅛ./;WKa|;x{q2 nLO|ݻA;8}[@L&ӽ??=܌iU|<0(ޗ{q4 M4>wvzDmDdo0nWnM`p׿at"cK8yx!nt7uǓѧ86s˨vzAwۿt/HF}+=xiwݟ|\*G7vqw#o<|0=\Yp{K@0L>y+Щ`E.y붏܅ "?\kGBYj0ChMȄl,}o'4v}; i y g0}XYH*kP3c+J~(fTl^kt'}Oۛnr@@!6c~'ZR1oK[ ]f onold&n_-2X{Yr {1 X:x㘱'aVAumoh046||}c,nX lCu''6͂E/c_?:Q(rE*(ީ{wo =EfOieiLbsZ$zƿcoQ.<AAi (/3E4Kb~DN OBzӵW+ NDkp3M2T`M(@p0ȗ%6*Cv\#4X _∇\jb՟;DU-TO|i˅ ,JYN{MUÛuby9CЅ_l#͢yfjיf"{$dPDO9 pz Y5mu8mÏB& ~ܳD~OK2!I5!e\iii d~!j) BW'deBE&}C{]>%O>맺VF75NүQٲǾyã4 2oaf*SI679!2!nff#-rEY^x"}IH4WTesVUx~Pz{˳}үWd-5 vPi~.I;r@u/5}Mk$6XGpbi$j;#؃K pX[@Z=ݕh=>{ŻgȳkiNyHhh~xq iv6gnӗXPǪE{֛k -_Rr34'o=qx ,:o+/E*u$C. Dؚ~GֲDfהFD˥;KLc TL~O#U?^6B?[/VIWfvڟB%x *"HA<]1+5gEf//*MB~Vө&p:Cִ嬪w64X$ϵ?s/ ^%'2nMCoRYt_BE IBrrK{iQk 2GVXig@mGP 2G1QM-^8lU(RSYgG ]oaCiD.*7 (p(o'O~?zfU )c=k^uCn¡J!]`{V [Bv.pU Qd?f"Q339Y9e+U!Eˌ& kzpO38+U&0 6K Ƽf$5#*{cuh Qe3&,_-pq(Z+L=GE"Ԁߥ:,/}NbihĞWOqC9a 9 ϏIFnr"j7^ bHHa+^SYGApڇdk@!42sMFDI`M_U}vAA2bX%*`? [?)JWuv$`8>C(hRJW(ֵ+@>5gNn if+&AI/(-^.L-ʃ,e5v%!S 5w?eJ{{{HAirb:)ebI0 #>x'ʌCL`,+C.A9N# ߈bLY5I:}/|d 7a  ySSHu}"/(8d#y\a:vI#*|z-9UhH4\J{􋂊.M{on J`S OJ-ᨘj7 Hv!O"0c9Soi" jhe6jA?#Mf૖evS_Fb@a¸z_.eۯٰz<Iaˣ?Œ@JA=QP¡\WETzJ-ĵ +uHz:dwjcA)(L'(:"5 O#PCD?)Ak. %d: ]U9}!Vy k?_W;H:V% ŕE PS>!)ue+zw;ҴRYP.c'MY s5FUM: brE~-EeiD&!$6vr?yͩm^tQIByD g S$^ϗH@IabVap#0:NU(t0jVVk(5^ ky3xV'~FT, bD/plsf$[҄e#10ҕS*PVL`H|&Մ(c D涒χM]F׌JC͊յrFs-:`sv}>1oy_:NlfA9'f~MF>#XOj ޵;# gX޺ڴeiëL \s>v\)SV%˜[QyVd+Xd+]% oٕl^Z#lwn1p0U^EJ)Z vOkm~8ٟ C=6r mf Zj\D_l1fiFZʹY@bP懑=[PnN "ĒT"-I'I&2 -N(TzE S5k ]ZzjjdaÞ6و`"sb$#н*q: ယ>(H+l]Ι"C,gI%rH ^Et Z^ƈ?j#w]T9;J=(l/,@4B-/sGIGSy-װybadžܵzM%Q,^O/AN lJ ϪV[Qh.WҨ#^\:ҏSw.ꕪU7pGM"?AC? m"wఱpCd>v% d,SɌKuh(Lo=ME-Ⴙ ܤ6p<%%iT|s>fUQblWKwNTFu']sAuÞۍb*n},%;pӥ.gP.i8Fۭa`B}]K9#m7%`S,. ?4tpa"2&9D5HKwN=?8P48|(Gp#إAI WmԑU9yHc;O )F@!WQK#,۫4ƞ˹ьnь_l@JuӦJU&E¼BjDy Zǭ4ϜluOWMg-YBF놩r=* 7d;V$7|}7[^0Tt.LbQDD,Q)W^JNmVLB$8*2p#*q 66V iqMwڠ^v%͞dSt.T4%ijA0;4 ͨ?? ~V[8Ƈ$@H .O{I9C&YŤ=P"?QUsz93~wn'98:y-z&iJȄ efu|~u|rz݌z;f'Dx0"QlJV=9;&tc ]7W''Q~o׈с#*F-8M9|n8x@Umcp>aX5$׈p=q~ u\^OϩVy|ֶ(+ 5IgEgFVmqݺ7Dz| 8z>6伍-'wܥsvA¾,T*:׈Ǖ "7n$ X: ŗJ5%+xlW'>usŏ6WٺD+5o˥G9m'b+.*$kxD1!#rtY*G0l jӧl' 6#dNYj|PJ火 ^g`91}rQq!!?'7Y6} $h}Fx+q1]Zl]) Bm3/{vKL˥s:ˠDŸhQگTCRei6}_g~_ޖ(kgIaW`Qf*`9˾6M6hrOH $lZu %{`3jޒ#dſ6ScpIޥ[$'ؒ9:>>@ِ#_޳'_7 !IE-cY|VYM8xyW^><'#'L&iąi7AzQ)ɛgO\mHʏi䖮:hvN;\hgqF3E1ϩYrPj[=Vv-ﳟJ ~2b@M͕k9;%Ɵ^qu֜ o%%Kg=H:c/*3k4QjͮQC̑5f2?!AZ0#?E;$db4d&G7b0wꅍ1߃.W7f| ծr[ߦҺ(&$!(<$vhs3~-A=D9g\!kV nC<:+ѦAN1!liRt!NXOY|G2d00`s =[/*i^U!o)Hh́%ꥪ1'!.nF]t,Ns \%<^VJQSq l'/GLܗiY 8#B=*OcjbdX!g}Х AąjlAAĚ^+i V ʇxdb F]/R9Q9jb$KeW݃/"eܶvfgvFQ`~BFrrڪѦlKkd*[ʏ%vGt} @#%t93y{m%;t\·=dB 3n@DR_ jmy唚biTh#>VL3Cݴ*~@,STL!8~*}bqPi8AEa dVO"=` ) ]\c:}$) b5v}qnegzB?p?eq28ɏnn| '?5K5S]<)>-$(M-R5F[54uZ^c%#9Բ"Rm寜#fNGSB됲U*]-[۶jt,c*y˔EL,a]? r]U%̵%PNKkJL.pos-}1N6-8ɤ:i`hS Mp\U;م#u܉ૂT'$Zu.]f.x>Q;o: _|X(klhoFmdlqiau/mB)MLf9qٽxM[#g-u#+O7f0Niug'C1Qds*mHIĮJk U8VEbcjΓRF_$=+QcEdS;ej\HJKbPbG #KIƧ곫iML{z7t津P/~U{Ѐ! iI뵏0pB,ˏι)m9 ;߽FE*Â&f%;7'^!t$EcN<O| mMƫ1u|`F#Z I@<FLiiۮhcܽ_U)+fxl? BqN]ơiu۶bf苘η iF1]hY4kSkkW}2`h2gaq_"i6%dAlc/]QX&,~R+_VrUnlb'7eJiHF6V_#NIua/7u|/)i`ۗŚFb}0dgm@rF6Or{/7c-`+d-}フPp4`)aa <6[ਣeZT&;!ퟠKef=׶P bVS艟r_b8ihorvg,X6Os ]&Q*f(WdrWb7ws_T kKȡ {0UKaXwEŹv& m-}jҟW08'|`ܣ+k'5E>Ȓ}a 4}@LMN4VAԀPkMURd͖(gg^6t_8M߬'D|i,3NQ0dϽOޠ5a2;V4|_(Ys "Xgo"2No|L&=uDl,P-y> YNI"/.%4CH9)DkV踅\xa_Eo7y ̹Q'ڞoW2||SsrYk-L0TWSk0@@8B 8V2AQK>km^f+.,捄O-)j|%s^}2H~Ή0 roO5-&h!_w?sIDgMkx4aݻN_U))%cB[2i+W<3aJ\Fs\%'ˠ}5{o.!dtjg:̵u5 Hc|ZlЎ^v\j˽6!eZI^w&kc O=9{YX*©r Hz?ŚJ(Rl:$Sv糫Jm6%*mWV! prMr^\]7h k
    Enjoying the preview?
    Page 1 of 1