Microneedle-mediated Transdermal and Intradermal Drug Delivery

By Ryan F. Donnelly, Thakur Raghu Raj Singh, Desmond I. J. Morrow and A. David Woolfson

Microneedles can be used for delivery of a wide range of drug substances for practically any medical condition and present a real opportunity for vaccines and medicines that are unsuitable for oral administration or conventional patch delivery.

Microneedle-mediated Transdermal and Intradermal Drug Delivery covers the major aspects relating to the use of microneedle arrays in enhancing drug delivery applications. It provides an overview of the various methods employed to design and produce microneedles, from the different materials involved to the importance of application methods. It carefully and critically reviews ongoing transdermal and intradermal delivery research using microneedles and includes the outcomes of in vivo animal and human studies. Importantly, it also discusses the safety and patient acceptability studies carried out to date. Finally, the book reviews the recent patents in microneedle research and describes the ongoing developments within industry that will determine the future of microneedle-mediated transdermal and intradermal drug delivery.

By an expert author team with practical experience in the design and development of drug delivery systems this is the only text that provides a comprehensive review of microneedle research in transdermal and intradermal drug delivery.

• Language: English
• Publisher: Wiley
• Release date: Jan 12, 2012
• ISBN: 9781119959656

Ryan F. Donnelly

Professor Ryan Donnelly holds the Chair in Pharmaceutical Technology. His research is centred on design and physicochemical characterisation of advanced polymeric drug delivery systems for transdermal and topical drug delivery, with a strong emphasis on improving therapeutic outcomes for patients. His bioadhesive patch design was used successfully in the clinic and has now been licensed to Swedish Pharma AB, for whom he acts as a Scientific Advisor. He is currently developing a range of novel microneedle technologies through independent research, but also in collaboration with the world’s leading transdermal patch manufacturer and several major pharma partners. Still at a relatively early stage of his career, he has obtained substantial RCUK, charity and industrial funding and authored over 300 peer-reviewed publications, including 4 patent applications, 4 textbooks, 19 book chapters and approximately 130 full papers. He has been an invited speaker at numerous national and international conferences.