The Biology of Extracellular Molecular Chaperones
()
About this ebook
Since the promulgation of the ‘molecular chaperone’ concept as a general cellular function to control the process of correct protein folding, a large number of molecular chaperones and protein folding catalysts have been identified, and it has been recognized that not all molecular chaperones are stress proteins and vice versa. The discovery of molecular chaperones as folding proteins went hand-in-hand with their recognition as potent immunogens in microbial infection. It was subsequently shown that administration of molecular chaperones such as Hsp60, Hsp70 or Hsp90 could inhibit experimental autoimmune diseases and cancer.
More recently evidence has accumulated to show that certain molecular chaperones are also present on the surface of cells or in extracellular fluids. A new paradigm is emerging: at least some molecular chaperones are secreted proteins with pro- or anti-inflammatory actions, regulating the immune response in human diseases such as coronary heart disease, diabetes and rheumatoid arthritis. In addition to having direct effects on cells, molecular chaperones can bind peptides and present them to T cells to modulate immune responses. This may be significant in the treatment of cancer.
This is the first book bringing leading researchers in this field together to review and discuss:
- our current knowledge of cell stress response and molecular chaperones
- the changing paradigms of protein trafficking and function
- cell stress proteins as immunomodulators and pro- and anti-inflammatory signalling molecules
- the role of these proteins in various chronic diseases and their potential as preventative or therapeutic agents.
The Biology of Extracellular Molecular Chaperones is of particular interest to immunologists, cell and molecular biologists, microbiologists and virologists, as well as clinical researchers working in cardiology, diabetes, rheumatoid arthritis and other inflammatory diseases.
Related to The Biology of Extracellular Molecular Chaperones
Titles in the series (37)
Pathological Pain: From Molecular to Clinical Aspects Rating: 0 out of 5 stars0 ratingsGeneration and Effector Functions of Regulatory Lymphocytes Rating: 0 out of 5 stars0 ratingsCancer and Inflammation Rating: 0 out of 5 stars0 ratingsThe Nature of Intelligence Rating: 0 out of 5 stars0 ratingsRetinal Dystrophies: Functional Genomics to Gene Therapy Rating: 0 out of 5 stars0 ratingsBiology of IGF-1: Its Interaction with Insulin in Health and Malignant States Rating: 0 out of 5 stars0 ratingsReversible Protein Acetylation Rating: 0 out of 5 stars0 ratingsAnaphylaxis Rating: 0 out of 5 stars0 ratingsMammalian TRP Channels as Molecular Targets Rating: 0 out of 5 stars0 ratingsPercept, Decision, Action: Bridging the Gaps Rating: 0 out of 5 stars0 ratingsOsteoarthritic Joint Pain Rating: 0 out of 5 stars0 ratingsInflammatory Bowel Disease: Crossroads of Microbes, Epithelium and Immune Systems Rating: 0 out of 5 stars0 ratingsNuclear Organization in Development and Disease Rating: 0 out of 5 stars0 ratingsStem Cells: Nuclear Reprogramming and Therapeutic Applications Rating: 0 out of 5 stars0 ratingsGenetics of Autoimmunity Rating: 0 out of 5 stars0 ratingsThe hERG Cardiac Potassium Channel: Structure, Function and Long QT Syndrome Rating: 0 out of 5 stars0 ratingsMolecular Mechanisms Influencing Aggressive Behaviours Rating: 0 out of 5 stars0 ratingsVascular Development Rating: 0 out of 5 stars0 ratingsSignalling Networks in Cell Shape and Motility Rating: 0 out of 5 stars0 ratingsHeart Failure: Molecules, Mechanisms and Therapeutic Targets Rating: 0 out of 5 stars0 ratingsEpithelial Anion Transport in Health and Disease: The Role of the SLC26 Transporters Family Rating: 0 out of 5 stars0 ratingsUnderstanding Nicotine and Tobacco Addiction Rating: 0 out of 5 stars0 ratingsInnate Immunity to Pulmonary Infection Rating: 4 out of 5 stars4/5Mast Cells and Basophils: Development, Activation and Roles in Allergic / Autoimmune Disease Rating: 0 out of 5 stars0 ratingsDecoding the Genomic Control of Immune Reactions Rating: 0 out of 5 stars0 ratingsDietary Supplements and Health Rating: 0 out of 5 stars0 ratingsPurinergic Signalling in Neuron-Glia Interactions Rating: 0 out of 5 stars0 ratingsNew Treatment Strategies for Dengue and Other Flaviviral Diseases Rating: 0 out of 5 stars0 ratingsGrowth Factors and Psychiatric Disorders Rating: 0 out of 5 stars0 ratingsCortical Development: Genes and Genetic Abnormalities Rating: 0 out of 5 stars0 ratings
Related ebooks
Mitochondrial Biology: New Perspectives Rating: 0 out of 5 stars0 ratingsReversible Protein Acetylation Rating: 0 out of 5 stars0 ratingsGenetics of Autoimmunity Rating: 0 out of 5 stars0 ratingsInnate Immunity to Pulmonary Infection Rating: 4 out of 5 stars4/5Anaphylaxis Rating: 0 out of 5 stars0 ratingsOsteoarthritic Joint Pain Rating: 0 out of 5 stars0 ratingsNovel and Re-emerging Respiratory Viral Diseases Rating: 0 out of 5 stars0 ratingsStem Cells: Nuclear Reprogramming and Therapeutic Applications Rating: 0 out of 5 stars0 ratingsCortical Development: Genes and Genetic Abnormalities Rating: 0 out of 5 stars0 ratingsDietary Supplements and Health Rating: 0 out of 5 stars0 ratingsVascular Development Rating: 0 out of 5 stars0 ratingsMammalian TRP Channels as Molecular Targets Rating: 0 out of 5 stars0 ratingsDecoding the Genomic Control of Immune Reactions Rating: 0 out of 5 stars0 ratingsDefining Optimal Immunotherapies for Type 1 Diabetes Rating: 0 out of 5 stars0 ratingsCancer and Inflammation Rating: 0 out of 5 stars0 ratingsGeneration and Effector Functions of Regulatory Lymphocytes Rating: 0 out of 5 stars0 ratingsMolecular Mechanisms Influencing Aggressive Behaviours Rating: 0 out of 5 stars0 ratingsSignalling Networks in Cell Shape and Motility Rating: 0 out of 5 stars0 ratingsInflammatory Bowel Disease: Crossroads of Microbes, Epithelium and Immune Systems Rating: 0 out of 5 stars0 ratingsEpithelial Anion Transport in Health and Disease: The Role of the SLC26 Transporters Family Rating: 0 out of 5 stars0 ratingsTinkering: The Microevolution of Development Rating: 0 out of 5 stars0 ratingsMast Cells and Basophils: Development, Activation and Roles in Allergic / Autoimmune Disease Rating: 0 out of 5 stars0 ratingsHeart Failure: Molecules, Mechanisms and Therapeutic Targets Rating: 0 out of 5 stars0 ratingsThe hERG Cardiac Potassium Channel: Structure, Function and Long QT Syndrome Rating: 0 out of 5 stars0 ratingsNuclear Organization in Development and Disease Rating: 0 out of 5 stars0 ratingsFatty Acid and Lipotoxicity in Obesity and Diabetes Rating: 0 out of 5 stars0 ratingsGrowth Factors and Psychiatric Disorders Rating: 0 out of 5 stars0 ratingsPurinergic Signalling in Neuron-Glia Interactions Rating: 0 out of 5 stars0 ratingsRetinal Dystrophies: Functional Genomics to Gene Therapy Rating: 0 out of 5 stars0 ratingsPromises and Limits of Reductionism in the Biomedical Sciences Rating: 0 out of 5 stars0 ratings
Biology For You
A Letter to Liberals: Censorship and COVID: An Attack on Science and American Ideals Rating: 3 out of 5 stars3/5Why We Sleep: Unlocking the Power of Sleep and Dreams Rating: 4 out of 5 stars4/5The Soul of an Octopus: A Surprising Exploration into the Wonder of Consciousness Rating: 4 out of 5 stars4/5Gut: The Inside Story of Our Body's Most Underrated Organ (Revised Edition) Rating: 4 out of 5 stars4/5The Sixth Extinction: An Unnatural History Rating: 4 out of 5 stars4/5All That Remains: A Renowned Forensic Scientist on Death, Mortality, and Solving Crimes Rating: 4 out of 5 stars4/5"Cause Unknown": The Epidemic of Sudden Deaths in 2021 & 2022 Rating: 5 out of 5 stars5/5Sapiens: A Brief History of Humankind Rating: 4 out of 5 stars4/5The Grieving Brain: The Surprising Science of How We Learn from Love and Loss Rating: 4 out of 5 stars4/5Anatomy 101: From Muscles and Bones to Organs and Systems, Your Guide to How the Human Body Works Rating: 4 out of 5 stars4/5The Winner Effect: The Neuroscience of Success and Failure Rating: 5 out of 5 stars5/5Lifespan: Why We Age—and Why We Don't Have To Rating: 4 out of 5 stars4/5Woman: An Intimate Geography Rating: 4 out of 5 stars4/5Mother of God: An Extraordinary Journey into the Uncharted Tributaries of the Western Amazon Rating: 4 out of 5 stars4/5Peptide Protocols: Volume One Rating: 4 out of 5 stars4/5Homo Deus: A Brief History of Tomorrow Rating: 4 out of 5 stars4/5Dopamine Detox: Biohacking Your Way To Better Focus, Greater Happiness, and Peak Performance Rating: 3 out of 5 stars3/5The Trouble With Testosterone: And Other Essays On The Biology Of The Human Predi Rating: 4 out of 5 stars4/5The Obesity Code: the bestselling guide to unlocking the secrets of weight loss Rating: 4 out of 5 stars4/5Written in Bone: Hidden Stories in What We Leave Behind Rating: 4 out of 5 stars4/5The Blood of Emmett Till Rating: 4 out of 5 stars4/5The Coming Plague: Newly Emerging Diseases in a World Out of Balance Rating: 4 out of 5 stars4/5The Great Mortality: An Intimate History of the Black Death, the Most Devastating Plague of All Time Rating: 4 out of 5 stars4/5How Emotions Are Made: The Secret Life of the Brain Rating: 4 out of 5 stars4/5Fantastic Fungi: How Mushrooms Can Heal, Shift Consciousness, and Save the Planet Rating: 5 out of 5 stars5/5The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race Rating: 4 out of 5 stars4/5Other Minds: The Octopus, the Sea, and the Deep Origins of Consciousness Rating: 4 out of 5 stars4/5Ultralearning: Master Hard Skills, Outsmart the Competition, and Accelerate Your Career Rating: 4 out of 5 stars4/5This Will Make You Smarter: 150 New Scientific Concepts to Improve Your Thinking Rating: 4 out of 5 stars4/5Your Brain: A User's Guide: 100 Things You Never Knew Rating: 4 out of 5 stars4/5
Reviews for The Biology of Extracellular Molecular Chaperones
0 ratings0 reviews