ACROSS
1. Substance that counteracts a poison (8) 5. Boundaries between different environments (8) 11. Means of operation (7) 12. Revival; renovation (7) 13. Castrated male rabbit (5) 14. Acid-tasting herb similar to dock (6) 15. Means of curdling milk (6) 16. Hybrid (5) 19. Essential ____ are extracted 23. Tightly tied bundle of hay (4) 24. Deadly disease of sheep and cattle due to a bacillus (7) 25. Wild rosebush (5) 26. Passive; inactive (5) 28. Plant diseases that cause shrivelling and withering (7) 30. Plant () grown for its herbage and oil-producing seeds (4) 32. Country bordered by Ghana, Burkina Faso and Benin (4) 35. Tracts of land used for cultivation or pasturage (5) 38. Relating to skin (6) 39. Reduce in status or reputation (6) 40. Area of low trees and shrubs (5) 42. Dense area of trees (7) 43. Line of descent (7) 44. Type of German dry white table wine (8) 45. Larva of a genus beetle found in granaries (8)