The worst thing that can happen on a Digital Command Control (DCC) layout is you get a short circuit - when a train derails or runs into a point, or for some other reason - because a lot of current can flow which can damage your booster and/or your trains.
My layout has two power districts, so if I get a short on one side of the layout and I happen to be looking at the other side, I may not notice the short because I don't see or hear the