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    What the 1918 flu pandemic can teach us about coronavirus drug trials | Laura Spinney

    In times of crisis, scientists have to make ethical decisions about new treatments – even if the evidence seems shaky • Laura Spinney is the author of Pale Rider: The Spanish Flu of 1918 and How it Changed the World• Coronavirus latest updates• See all our coronavirus coverage
    by Laura Spinney Apr 05, 2020 3 minutes
    A queue in San Francisco during the Spanish flu epidemic, 1918. Photograph: Hamilton Henry Dobbin/California State Library/EPA

    Sometimes the parallels between this pandemic and previous ones are uncanny.

    Take hydroxychloroquine, the anti-malarial drug that regulatory agencies all over the world are now hastily authorising for the treatment of hospitalised Covid-19 patients. Outside hospitals, Donald Trump and the Brazilian president, Jair Bolsonaro, have expressed enthusiasm for the drug, people are breaking social distancing rules to get it, and there have been cases of poisoning due to inappropriate self-medication.

    The run on hydroxychloroquine is the result of a at a hospital in Marseille that, though promising, has not yet provided the required standard of proof

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