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Dedicated to Research - Sagarika Datta
Copyright © 2022 by Sagarika Datta.
All rights reserved. No part of this book may be reproduced or transmitted
in any form or by any means, electronic or mechanical, including photocopying,
recording, or by any information storage and retrieval system,
without permission in writing from the copyright owner.
Any people depicted in stock imagery provided by Getty Images are models,
and such images are being used for illustrative purposes only.
Certain stock imagery © Getty Images.
Rev. date: 08/15/2022
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CONTENTS
Acknowledgment
Role of calcium channel blocker in excessive mast cell degranulation
Metabolic Acidosis & it’s connection with other diseases
Effectivity of Flunarizine in controlling acidosis induced headache
Mathematics Braille
Segmentation of Bangla Unconstrained Handwritten Text
ACKNOWLEDGMENT
THE PRE-PRINTS ARE TAKEN FROM RESEARCH SQUARE. THANKS TO RESEARCH SQUARE. THANKS TO THE INTERNATIONAL COUNCIL FOR EDUCATION OF PEOPLE WITH VISUAL IMPAIRMENT AND WEBEL MEDIATRONICS LTD. THE PUBLISHED ARTICLE(PORTION) IN IEEE IS TAKEN FROM HTTPS://IEEEXPLORE.IEEE.ORG/
ROLE OF CALCIUM
CHANNEL BLOCKER IN
EXCESSIVE MAST CELL
DEGRANULATION
Sagarika Datta
Abstract
Background:
I present a case of a female patient, age 45 years, for whom the uncontrolled mast cell degranulation created many issues related to allergy like, skin rash, itching, breathing discomfort, frequent throat infection, GERD, migraine, fibromyalgia, peripheral neuropathy, depression, anxiety disorder, constipation etc. For the patient, it was observed that calcium channel blockers seem to control the unnecessary and uncontrolled mast cell degranulation. CCB seemed to have a role to play in mast cell degranulation.
Case presentation:
When the patient is taking either Flunarizine or Pregabalin or both together, the need for antihistamine and montelukast are very low. The patient suffers less throat infection while Flunarizine or Pregabalin are being taken. More the dose of Pregabalin less the occurrence of any type of allergy (food, pollen, dust etc.). The requirement of corticosteroid inhaler for breathing discomfort is also less. Frequency of body pain, migraine is minimal. Occurrence of stomach acid or GERD or digestion disorder is also very less. In terms of mood
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